An Unholy Triad Birth of a Plague: Episode 2

Pure Media Australia (2025)

Film Review

This episode explains the specific functions of six of the ORFs (Open Reading Fields) inserted into bat coronavirus to weaponize Covid 19.

In general ORFs or open reading fields serve as a genetic blueprint for protein that govern virus behavior, in this case to hijack the functions of the host they infect and that person’s immune system.

ORF1A and ORF1B – encode for proteins involved in viral replication.

ORF3A – inhibit autophagy (the ability of the cell to clear foreign material).

ORF6 – helps the virus avoid detection by inhibiting interferon, which coordinates the immune response to viral infection.

ORF8 – inhibits apoptosis (automatic programed cell death), which enhances viral entry into human cells.

ORF11 (developed at the Wuhan Institute of Virology) – enhances viral entry into human cells.